Applying multiple imputation to multi-item patient reported outcome measures: advantages and disadvantages of imputing at the item, sub-scale or score level

<p>Missing data are generally unavoidable in clinical trials (RCTs), particularly in patient reported outcome measures (PROMs) and can introduce bias into the study results. Multiple imputation (MI) is considered to be one of the most reliable methods to handle this problem.</p> <p>...

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Bibliographic Details
Main Authors: Rombach, I, Burke, O, Jenkinson, C, Gray, A, Rivero-Arias, O
Format: Conference item
Published: BioMed Central 2016