Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

Eukaryotic protein kinases are generally classified as being either tyrosine or serine-threonine specific. Though not evident from inspection of their primary sequences, many serine-threonine kinases display a significant preference for serine or threonine as the phosphoacceptor residue. Here we sho...

Full description

Bibliographic Details
Main Authors: Chen, C, Ha, B, Thévenin, A, Lou, H, Zhang, R, Boggon, T, Turk, B, Yip, K, Gerstein, M, Peterson, JR, Kim, P, Filippakopoulos, P, Knapp, S
Format: Journal article
Published: 2014