Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduc...

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Bibliographic Details
Main Authors:	Crawford, H, Prado, J, Leslie, A, Hué, S, Honeyborne, I, Reddy, S, van der Stok, M, Mncube, Z, Brander, C, Rousseau, C, Mullins, J, Kaslow, R, Goepfert, P, Allen, S, Hunter, E, Mulenga, J, Kiepiela, P, Walker, B, Goulder, P
Format:	Journal article
Language:	English
Published:	2007

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

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