Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduc...
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Bibliographic Details
| Main Authors: |
Crawford, H,
Prado, J,
Leslie, A,
Hué, S,
Honeyborne, I,
Reddy, S,
van der Stok, M,
Mncube, Z,
Brander, C,
Rousseau, C,
Mullins, J,
Kaslow, R,
Goepfert, P,
Allen, S,
Hunter, E,
Mulenga, J,
Kiepiela, P,
Walker, B,
Goulder, P |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2007
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