Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduc...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797097906265653248 |
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| author | Crawford, H Prado, J Leslie, A Hué, S Honeyborne, I Reddy, S van der Stok, M Mncube, Z Brander, C Rousseau, C Mullins, J Kaslow, R Goepfert, P Allen, S Hunter, E Mulenga, J Kiepiela, P Walker, B Goulder, P |
| author_facet | Crawford, H Prado, J Leslie, A Hué, S Honeyborne, I Reddy, S van der Stok, M Mncube, Z Brander, C Rousseau, C Mullins, J Kaslow, R Goepfert, P Allen, S Hunter, E Mulenga, J Kiepiela, P Walker, B Goulder, P |
| author_sort | Crawford, H |
| collection | OXFORD |
| description | HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia. |
| first_indexed | 2024-03-07T05:02:00Z |
| format | Journal article |
| id | oxford-uuid:d8959f63-1e25-43ef-97d5-2ec5f1b6562d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:02:00Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:d8959f63-1e25-43ef-97d5-2ec5f1b6562d2022-03-27T08:49:53ZCompensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d8959f63-1e25-43ef-97d5-2ec5f1b6562dEnglishSymplectic Elements at Oxford2007Crawford, HPrado, JLeslie, AHué, SHoneyborne, IReddy, Svan der Stok, MMncube, ZBrander, CRousseau, CMullins, JKaslow, RGoepfert, PAllen, SHunter, EMulenga, JKiepiela, PWalker, BGoulder, PHLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia. |
| spellingShingle | Crawford, H Prado, J Leslie, A Hué, S Honeyborne, I Reddy, S van der Stok, M Mncube, Z Brander, C Rousseau, C Mullins, J Kaslow, R Goepfert, P Allen, S Hunter, E Mulenga, J Kiepiela, P Walker, B Goulder, P Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title_full | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title_fullStr | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title_full_unstemmed | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title_short | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. |
| title_sort | compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant hla b 5703 restricted gag epitope in chronic human immunodeficiency virus type 1 infection |
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