Structural and mechanistic studies on PHD2 and the discovery of potential inhibitors
<p>Human prolyl hydroxylases isoforms 1-3 (HsPHD1-3) are hypoxia sensing 2-oxoglutarate (2OG)-dependent oxygenases that catalyse post-translational modifications of hypoxia-inducible factor (HIFα). The PHDs catalyse the trans-4-prolyl hydroxylation of the oxygen degradation domains (ODDs) in...
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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