Lung microbiome dynamics in COPD exacerbations

Lung microbiome dynamics in COPD exacerbations

Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung microbiome during COPD exacerbations and its potential role in disease aetiology remain poorly understood. We completed a longitud...

Descripció completa

Dades bibliogràfiques
Autors principals:	Wang, Z, Bafadhel, M, Haldar, K, Spivak, A, Mayhew, D, Miller, BE, Tal-Singer, R, Johnston, SL, Ramsheh, MY, Barer, MR, Brightling, CE, Brown, JR
Format:	Journal article
Idioma:	English
Publicat:	European Respiratory Society 2016

Ítems similars

Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics
per: Haldar, K, et al.
Publicat: (2017)

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function
per: Bafadhel M, et al.
Publicat: (2015-06-01)

Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations.
per: Barker, B, et al.
Publicat: (2015)

Biological exacerbation clusters demonstrate asthma and COPD overlap with distinct mediator and microbiome profiles
per: Ghebre, M, et al.
Publicat: (2018)

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD
per: Thulborn SJ, et al.
Publicat: (2017-04-01)

Inhaled glucocorticoids and COPD exacerbations.
per: Brightling, C, et al.
Publicat: (2015)

Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD.
per: Bafadhel, M, et al.
Publicat: (2011)

Late breaking abstract - Resistomics of sputum from COPD and healthy subjects reveals bacterial load-related prevalence of antimicrobial-resistance-encoding genes
per: Ramsheh, M, et al.
Publicat: (2018)

Sputum microbiomic clustering in asthma and COPD reveals a Haemophilus‐predominant subgroup
per: Diver, S, et al.
Publicat: (2019)

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.
per: Thulborn, S, et al.
Publicat: (2017)

Sputum Moraxella catarrhalis strains exhibit diversity within and between COPD subjects
per: George LM, et al.
Publicat: (2018-11-01)

Resistome analyses of sputum from COPD and healthy subjects reveals bacterial load-related prevalence of target genes
per: Ramsheh, MY, et al.
Publicat: (2019)

COPD exacerbations: transforming outcomes through research
per: Hurst, JR, et al.
Publicat: (2018)

Blood Eosinophils and outcomes in severe hospitalized exacerbations of COPD
per: Bafadhel, M, et al.
Publicat: (2016)

Building toolkits for COPD exacerbations: lessons from the past and present
per: Sapey, E, et al.
Publicat: (2019)

Lung microbiology and exacerbations in COPD
per: Beasley V, et al.
Publicat: (2012-08-01)

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis.
per: Bafadhel, M, et al.
Publicat: (2014)

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
per: Eltboli, O, et al.
Publicat: (2014)

Detection of cell-dissociated non-typeable haemophilus influenzae in the airways of patients with chronic obstructive pulmonary disease
per: Thulborn, SJ, et al.
Publicat: (2020)

Cell-dissociated haemophilus influenzae and bacteria-associated inflammatory mediators in the airways of patients with chronic obstructive pulmonary disease
per: Thulborn, SJ, et al.
Publicat: (2017)

Detection of Cell-Dissociated Non-Typeable Haemophilus influenzae in the Airways of Patients with Chronic Obstructive Pulmonary Disease
per: Thulborn SJ, et al.
Publicat: (2020-06-01)

Is it time to give up on "self-management" of COPD exacerbations?
per: Ramakrishnan, S, et al.
Publicat: (2020)

Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial.
per: Bafadhel, M, et al.
Publicat: (2012)

Aspergillus fumigatus during stable state and exacerbations of COPD.
per: Bafadhel, M, et al.
Publicat: (2014)

Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab
per: George L, et al.
Publicat: (2019-06-01)

Benralizumab for the prevention of COPD exacerbations
per: Criner, G, et al.
Publicat: (2019)

Characterisation of exacerbations of severe eosinophilic asthma (SEA) on mepolizumab compared to placebo
per: Shrimanker, R, et al.
Publicat: (2017)

Lung microbiome of stable and exacerbated COPD patients in Tshwane, South Africa
per: T. Goolam Mahomed, et al.
Publicat: (2021-10-01)

Renaming COPD exacerbations: the UK respiratory nursing perspective
per: Christine Mwasuku, et al.
Publicat: (2021-09-01)

Characterising non-eosinophilic COPD
per: Hambleton, K, et al.
Publicat: (2015)

Overcoming Therapeutic Inertia to Reduce the Risk of COPD Exacerbations: Four Action Points for Healthcare Professionals
per: Singh D, et al.
Publicat: (2021-11-01)

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial
per: Siva R, et al.
Publicat: (2014-02-01)

Deciphering the impact of microbial interactions on COPD exacerbation: An in-depth analysis of the lung microbiome
per: Hamidreza Taherkhani, et al.
Publicat: (2024-02-01)

Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
per: Bafadhel, M, et al.
Publicat: (2011)

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD
per: Mike Lonergan, et al.
Publicat: (2020-07-01)

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease
per: Barker BL, et al.
Publicat: (2014-09-01)

Characteristics of the sputum microbiome in COPD exacerbations and correlations between clinical indices
per: Linfan Su, et al.
Publicat: (2022-02-01)

Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort.
per: Dave Singh, et al.
Publicat: (2014-01-01)

Post-pandemic seasonal dynamics of hospitalised COPD exacerbations and aetiologies in the COPD population
per: Hnin Aung, et al.
Publicat: (2024-09-01)

Exacerbations of COPD
per: Pavord ID, et al.
Publicat: (2016-02-01)