Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype.

Eitemau Tebyg

• Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.
  gan: Halford, SE, et al.
  Cyhoeddwyd: (2003)
• Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
  gan: Beck, N, et al.
  Cyhoeddwyd: (1997)
• Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
  gan: Thirlwell, C, et al.
  Cyhoeddwyd: (2007)
• Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
  gan: Sieber, O, et al.
  Cyhoeddwyd: (2003)
• The multiple colorectal adenoma phenotype and MYH, a base excision repair gene.
  gan: Lipton, L, et al.
  Cyhoeddwyd: (2004)