Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromo...

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Bibliographic Details
Main Authors:	Antonova-Koch, Y, Meister, S, Abraham, M, Luth, MR, Ottilie, S, Lukens, AK, Sakata-Kato, T, Vanaerschot, M, Owen, E, Rodriguez, JC, Maher, SP, Calla, J, Plouffe, D, Zhong, Y, Chen, K, Chaumeau, V, Conway, AJ, McNamara, CW, Ibanez, M, Gagaring, K, Serrano, FN, Eribez, K, Taggard, CM, Cheung, AL, Lincoln, C, Ambachew, B, Rouillier, M, Siegel, D, Nosten, F, Kyle, DE, Gamo, F-J, Zhou, Y, Llinás, M, Fidock, DA, Wirth, DF, Burrows, J, Campo, B, Winzeler, EA
Format:	Journal article
Language:	English
Published:	American Association for the Advancement of Science 2018

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

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