Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

OBJECTIVE: Susceptibility to inflammatory arthritis is determined by a complex set of environmental and genetic factors, but only a portion of the genetic effect can be explained. Conventional genome-wide screens of arthritis models using crosses between inbred mice have been hampered by the low res...

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Bibliographic Details
Main Authors: Johnsen, A, Valdar, W, Golden, L, Ortiz-Lopez, A, Hitzemann, R, Flint, J, Mathis, D, Benoist, C
Format: Journal article
Language:English
Published: 2011