Imprinting of the G(s)alpha gene GNAS1 in the pathogenesis of acromegaly.
Approximately 40% of growth hormone-secreting pituitary adenomas have somatic mutations in the GNAS1 gene (the so-called gsp oncogene). These mutations at codon 201 or codon 227 constitutively activate the alpha subunit of the adenylate cyclase-stimulating G protein G(s). GNAS1 is subject to a compl...
Main Authors: | , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2001
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