Structural characterization of mammalian bHLH-PAS transcription factors
The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH–PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2016
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| _version_ | 1826299619941810176 |
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| author | Wu, D Rastinejad, F |
| author_facet | Wu, D Rastinejad, F |
| author_sort | Wu, D |
| collection | OXFORD |
| description | The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH–PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1. Most bHLH-PAS proteins have been genetically linked to variety of diseases in humans, including cancers, metabolic syndromes and psychiatric conditions. To function as transcription factors, the bHLH-PAS proteins must form heterodimeric complexes. Recent crystallographic studies of HIF-α-ARNT and CLOCK-BMAL1 complexes have unveiled the organization of their multi-domain bHLH-PAS-A-PAS-B segments, revealing how these architectures can give rise to unique patterns of heterodimerization. As our structural understanding becomes better integrated with ligand-discovery and target gene identification, a more comprehensive picture of their architectural and functional properties will emerge.
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| first_indexed | 2024-03-07T05:04:42Z |
| format | Journal article |
| id | oxford-uuid:d981b163-4452-4974-b2fa-96e0b608e475 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:04:42Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:d981b163-4452-4974-b2fa-96e0b608e4752022-03-27T08:56:28ZStructural characterization of mammalian bHLH-PAS transcription factorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d981b163-4452-4974-b2fa-96e0b608e475EnglishSymplectic ElementsElsevier2016Wu, DRastinejad, FThe mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH–PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1. Most bHLH-PAS proteins have been genetically linked to variety of diseases in humans, including cancers, metabolic syndromes and psychiatric conditions. To function as transcription factors, the bHLH-PAS proteins must form heterodimeric complexes. Recent crystallographic studies of HIF-α-ARNT and CLOCK-BMAL1 complexes have unveiled the organization of their multi-domain bHLH-PAS-A-PAS-B segments, revealing how these architectures can give rise to unique patterns of heterodimerization. As our structural understanding becomes better integrated with ligand-discovery and target gene identification, a more comprehensive picture of their architectural and functional properties will emerge. |
| spellingShingle | Wu, D Rastinejad, F Structural characterization of mammalian bHLH-PAS transcription factors |
| title | Structural characterization of mammalian bHLH-PAS transcription factors |
| title_full | Structural characterization of mammalian bHLH-PAS transcription factors |
| title_fullStr | Structural characterization of mammalian bHLH-PAS transcription factors |
| title_full_unstemmed | Structural characterization of mammalian bHLH-PAS transcription factors |
| title_short | Structural characterization of mammalian bHLH-PAS transcription factors |
| title_sort | structural characterization of mammalian bhlh pas transcription factors |
| work_keys_str_mv | AT wud structuralcharacterizationofmammalianbhlhpastranscriptionfactors AT rastinejadf structuralcharacterizationofmammalianbhlhpastranscriptionfactors |