α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
α-Synuclein has been implicated in the pathogenesis of Parkinson's disease based on mutations in familial cases of the disease and its presence in Lewy bodies. Here we show that over-expression of wild-type human α-synuclein is sufficient to induce inclusion formation in SH-SY5Y cells. In this...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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