DMRT1 regulates human germline commitment

Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epigenetic programme and competence for gametogenesis. Here we follow the progression of nascent PGC-like cells derived from human embryonic stem cells in vitro. We show that switchin...

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Main Authors: Irie, N, Lee, S-M, Lorenzi, V, Xu, H, Chen, J, Inoue, M, Kobayashi, T, Sancho-Serra, C, Drousioti, E, Dietmann, S, Vento-Tormo, R, Song, C-X, Surani, MA
Format: Journal article
Jezik:English
Izdano: Springer Nature 2023