Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.

Patients with glucocorticoid excess develop central obesity, yet in simple obesity, circulating glucocorticoid levels are normal. We have suggested that the increased activity and expression of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) generating active cortisol from cortiso...

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Main Authors: Tomlinson, J, Moore, J, Cooper, MS, Bujalska, I, Shahmanesh, M, Burt, C, Strain, A, Hewison, M, Stewart, P
格式: Journal article
语言:English
出版: 2001