Breaking the paradigm: early insights from mammalian DNA breakomes

DNA double-strand breaks (DSBs) can result from both exogenous and endogenous sources and are potentially toxic lesions to the human genome. If improperly repaired, DSBs can threaten genome integrity and contribute to premature ageing, neurodegenerative disorders and carcinogenesis. Through decades...

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Detalhes bibliográficos
Principais autores: Saayman, X, Esashi, F
Formato: Journal article
Idioma:English
Publicado em: Federation of European Biochemical Societies 2021