The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5

<p>The leishmaniases are a collection of neglected tropical diseases caused by <em>Leishmania</em> parasites that are epidemic across Africa, Asia, and Latin America. <em>Leishmania</em> have complex lifecycles, adopting a range of phenotypes to survive in multiple host...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Carter, JL
Awduron Eraill:	Conway, SJ
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2023
Pynciau:	Chemical biology Organic chemistry

Eitemau Tebyg

Development of small molecule inhibitors of the bromodomain-histone interaction
gan: Rooney, TPC
Cyhoeddwyd: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
gan: Hay, D
Cyhoeddwyd: (2014)

Developing inhibitors of bromodomain-histone interactions
gan: Hewings, D
Cyhoeddwyd: (2014)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
gan: McArdle, DJB
Cyhoeddwyd: (2023)

Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes.
gan: Encar García-Oliver, et al.
Cyhoeddwyd: (2017-01-01)

Towards a small molecule inhibitor of Lactate Dehydrogenase-A
gan: Lomas, A
Cyhoeddwyd: (2011)

Small molecule colorimetric and fluorescent probes for specific protein detection
gan: Egleton, JE
Cyhoeddwyd: (2015)

Small molecule inhibitors and substrate analyses of protein arginine methyltransferases
gan: Varney, A
Cyhoeddwyd: (2015)

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
gan: Bunce, HAP
Cyhoeddwyd: (2021)

A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism
gan: Muzammal Hussain, et al.
Cyhoeddwyd: (2022-07-01)

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential
gan: Kaiyao Wei, et al.
Cyhoeddwyd: (2025-03-01)

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain
gan: Platt, MA
Cyhoeddwyd: (2024)

A potent and selective inhibitor of a histone demethylase
gan: England, K
Cyhoeddwyd: (2016)

Development of ligands to target bromodomain-histone interactions
gan: Jennings, L
Cyhoeddwyd: (2015)

Discovery of epigenetic probes against the bromodomain family of proteins
gan: Clark, P
Cyhoeddwyd: (2015)

Small-molecule bromodomain inhibitors for cancer therapy
gan: Qi, J, et al.
Cyhoeddwyd: (2010)

Developing small molecule inhibitors of bromodomain-histone interactions
gan: Wilson, B, et al.
Cyhoeddwyd: (2015)

Selective modification and detection of the DNA bases
gan: Wallace, E
Cyhoeddwyd: (2011)

Novel methods in glycosaminoglycan and proteoglycan synthesis
gan: Modak, A
Cyhoeddwyd: (2015)

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
gan: Alishahi, S
Cyhoeddwyd: (2013)

Chemical tools to probe the role of bromodomains in the parasite Trypanosoma cruzi
gan: Laurin, CMC
Cyhoeddwyd: (2019)

Bromodomain factor 5 is an essential regulator of transcription in Leishmania
gan: Nathaniel G. Jones, et al.
Cyhoeddwyd: (2022-07-01)

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains
gan: Boyd, AM
Cyhoeddwyd: (2024)

Site-specific chemical modification of antibodies for the modulation of function
gan: Gunnoo, S, et al.
Cyhoeddwyd: (2013)

Radical chemistry for selective modification of native residues in proteins
gan: Imiolek, M
Cyhoeddwyd: (2020)

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria
gan: Haslam, C
Cyhoeddwyd: (2019)

Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction
gan: Rooney, T, et al.
Cyhoeddwyd: (2012)

Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting
gan: Glawar, AFG
Cyhoeddwyd: (2013)

Design, synthesis and application of novel light-activated molecular probes
gan: Stanton-Humphreys, M, et al.
Cyhoeddwyd: (2010)

Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
gan: Goodfellow, J, et al.
Cyhoeddwyd: (2011)

Development of tuberculosis imaging probes based on sugars and proteins
gan: Khan, RMN
Cyhoeddwyd: (2020)

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3)
gan: Victoria L. Alonso, et al.
Cyhoeddwyd: (2024-10-01)

Novel protein editing technologies to probe cellular damage
gan: Poh, AWJ
Cyhoeddwyd: (2023)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
gan: Hammerstein, A
Cyhoeddwyd: (2011)

Recent developments in one-pot stepwise synthesis (OPSS) of small molecules
gan: Xiaoming Ma, et al.
Cyhoeddwyd: (2022-09-01)

Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.
gan: Martinez-Campa, C, et al.
Cyhoeddwyd: (2004)

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms
gan: Ethan Ashby, et al.
Cyhoeddwyd: (2022-06-01)

Olefin metathesis for site-selective protein modification
gan: Lin, YA
Cyhoeddwyd: (2013)

Dynamic combinatorial mass spectrometry for 2-oxoglutarate oxygenase inhibition
gan: Demetriades, M
Cyhoeddwyd: (2013)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
gan: Saliba, R, et al.
Cyhoeddwyd: (2014)