The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5

<p>The leishmaniases are a collection of neglected tropical diseases caused by <em>Leishmania</em> parasites that are epidemic across Africa, Asia, and Latin America. <em>Leishmania</em> have complex lifecycles, adopting a range of phenotypes to survive in multiple host...

Deskribapen osoa

Xehetasun bibliografikoak
Egile nagusia:	Carter, JL
Beste egile batzuk:	Conway, SJ
Formatua:	Thesis
Hizkuntza:	English
Argitaratua:	2023
Gaiak:	Chemical biology Organic chemistry

Antzeko izenburuak

Development of small molecule inhibitors of the bromodomain-histone interaction
nork: Rooney, TPC
Argitaratua: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
nork: Hay, D
Argitaratua: (2014)

Developing inhibitors of bromodomain-histone interactions
nork: Hewings, D
Argitaratua: (2014)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
nork: McArdle, DJB
Argitaratua: (2023)

Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes.
nork: Encar García-Oliver, et al.
Argitaratua: (2017-01-01)

Towards a small molecule inhibitor of Lactate Dehydrogenase-A
nork: Lomas, A
Argitaratua: (2011)

Small molecule colorimetric and fluorescent probes for specific protein detection
nork: Egleton, JE
Argitaratua: (2015)

Small molecule inhibitors and substrate analyses of protein arginine methyltransferases
nork: Varney, A
Argitaratua: (2015)

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
nork: Bunce, HAP
Argitaratua: (2021)

A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism
nork: Muzammal Hussain, et al.
Argitaratua: (2022-07-01)

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential
nork: Kaiyao Wei, et al.
Argitaratua: (2025-03-01)

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain
nork: Platt, MA
Argitaratua: (2024)

A potent and selective inhibitor of a histone demethylase
nork: England, K
Argitaratua: (2016)

Development of ligands to target bromodomain-histone interactions
nork: Jennings, L
Argitaratua: (2015)

Discovery of epigenetic probes against the bromodomain family of proteins
nork: Clark, P
Argitaratua: (2015)

Small-molecule bromodomain inhibitors for cancer therapy
nork: Qi, J, et al.
Argitaratua: (2010)

Developing small molecule inhibitors of bromodomain-histone interactions
nork: Wilson, B, et al.
Argitaratua: (2015)

Selective modification and detection of the DNA bases
nork: Wallace, E
Argitaratua: (2011)

Novel methods in glycosaminoglycan and proteoglycan synthesis
nork: Modak, A
Argitaratua: (2015)

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
nork: Alishahi, S
Argitaratua: (2013)

Chemical tools to probe the role of bromodomains in the parasite Trypanosoma cruzi
nork: Laurin, CMC
Argitaratua: (2019)

Bromodomain factor 5 is an essential regulator of transcription in Leishmania
nork: Nathaniel G. Jones, et al.
Argitaratua: (2022-07-01)

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains
nork: Boyd, AM
Argitaratua: (2024)

Site-specific chemical modification of antibodies for the modulation of function
nork: Gunnoo, S, et al.
Argitaratua: (2013)

Radical chemistry for selective modification of native residues in proteins
nork: Imiolek, M
Argitaratua: (2020)

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria
nork: Haslam, C
Argitaratua: (2019)

Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction
nork: Rooney, T, et al.
Argitaratua: (2012)

Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting
nork: Glawar, AFG
Argitaratua: (2013)

Design, synthesis and application of novel light-activated molecular probes
nork: Stanton-Humphreys, M, et al.
Argitaratua: (2010)

Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
nork: Goodfellow, J, et al.
Argitaratua: (2011)

Development of tuberculosis imaging probes based on sugars and proteins
nork: Khan, RMN
Argitaratua: (2020)

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3)
nork: Victoria L. Alonso, et al.
Argitaratua: (2024-10-01)

Novel protein editing technologies to probe cellular damage
nork: Poh, AWJ
Argitaratua: (2023)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
nork: Hammerstein, A
Argitaratua: (2011)

Recent developments in one-pot stepwise synthesis (OPSS) of small molecules
nork: Xiaoming Ma, et al.
Argitaratua: (2022-09-01)

Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.
nork: Martinez-Campa, C, et al.
Argitaratua: (2004)

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms
nork: Ethan Ashby, et al.
Argitaratua: (2022-06-01)

Olefin metathesis for site-selective protein modification
nork: Lin, YA
Argitaratua: (2013)

Dynamic combinatorial mass spectrometry for 2-oxoglutarate oxygenase inhibition
nork: Demetriades, M
Argitaratua: (2013)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
nork: Saliba, R, et al.
Argitaratua: (2014)