Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight

Eitemau Tebyg

• Type 2 diabetes risk alleles are associated with reduced size at birth.
  gan: Freathy, R, et al.
  Cyhoeddwyd: (2009)
• Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
  gan: Pascoe, L, et al.
  Cyhoeddwyd: (2007)
• Common variation in the FTO (fused toes) gene is strongly associated with adiposity measures in the northern finnish birth cohort of 1966
  gan: Bennett, A, et al.
  Cyhoeddwyd: (2007)
• Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
  gan: Freathy, R, et al.
  Cyhoeddwyd: (2007)
• Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction.
  gan: Minton, J, et al.
  Cyhoeddwyd: (2007)