Paternal age effect mutations in germ cell development: pathological correlates in normal testis and testicular tumours
<p>Pathogenic gain-of-function mutations associated with increased paternal age, albeit harmful to embryonic development, are paradoxically enriched in the normal testis. Evidence from previous studies indicates that these so-called paternal age-effect mutations confer a proliferative advantag...
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| Médium: | Diplomová práce |
| Jazyk: | English |
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2011
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