Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes
Stereoselective biocatalysis by crotonase superfamily enzymes is exemplified by use of engineered 5-carboxymethylproline synthases (CMPSs) for preparation of functionalized 5-carboxymethylproline (5-CMP) derivatives methylated at two positions (i.e. C2/C6, C3/C6 and C5/C6), including products with a...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2016
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