Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.

Two soluble tumour-necrosis-factor-alpha(TNF)-binding proteins are derived from the extracellular domains of the p55 and p75 TNF receptors. They are considered to play a pivotal regulatory role in TNF-mediated inflammatory processes, including diseases such as rheumatoid arthritis, by competing with...

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Bibliographic Details
Main Authors: Corcoran, A, Barrett, K, Turner, M, Brown, A, Kissonerghis, A, Gadnell, M, Gray, P, Chernajovsky, Y, Feldmann, M
Format: Journal article
Language:English
Published: 1994