Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

Hereditary mixed polyposis syndrome (HMPS) is characterized by apparent autosomal dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma occurring in a high proportion of affected individuals. Here, we use genetic mapping, copy-number analysis, exclusion of mutations b...

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Main Authors:	Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2012

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

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