Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations

Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations

Islet β-cells are responsible for secreting all circulating insulin in response to rising plasma glucose concentrations. These cells are a phenotypically diverse population that express great functional heterogeneity. In mice, certain β-cells (termed ‘hubs’) have been shown to be crucial for dictati...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Lei, C, Kellard, J, Hara, M, Johnson, J, Rodriguez, B, Briant, L
Fformat:	Journal article
Cyhoeddwyd:	Taylor and Francis 2018

Eitemau Tebyg

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations
gan: Christopher H Emfinger, et al.
Cyhoeddwyd: (2023-10-01)

Insulin modulates the frequency of Ca2+ oscillations in mouse pancreatic islets.
gan: Boah Lee, et al.
Cyhoeddwyd: (2017-01-01)

Functional identification of islet cell types by electrophysiological fingerprinting
gan: Briant, L, et al.
Cyhoeddwyd: (2017)

RGD-modified injectable hydrogel maintains islet beta-cell survival and function
gan: Tianshu Lan, et al.
Cyhoeddwyd: (2020-10-01)

Maintaining islet quality during culture
gan: Rappel, Michael J
Cyhoeddwyd: (2007)

Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.
gan: Craig S Nunemaker, et al.
Cyhoeddwyd: (2009-12-01)

Ca2+i and the pancreatic α cell – intrinsic regulation and dysfunction in type 2 diabetes
gan: Kellard, J
Cyhoeddwyd: (2019)

Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans.
gan: Zhang, Q, et al.
Cyhoeddwyd: (2008)

The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans.
gan: Deborah A Striegel, et al.
Cyhoeddwyd: (2015-08-01)

CPT1a-dependent long-chain fatty acid oxidation contributes to maintaining glucagon secretion from pancreatic islets
gan: Briant, LJB, et al.
Cyhoeddwyd: (2018)

Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
gan: Melissa T Adams, et al.
Cyhoeddwyd: (2021-07-01)

Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations
gan: Erli Jin, et al.
Cyhoeddwyd: (2025-02-01)

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets
gan: Linford J.B. Briant, et al.
Cyhoeddwyd: (2018-06-01)

Synergistic Effect of Hyperglycemia and Suppression on Adult Mouse Islet Beta Cell Replication
gan: Szu-Tah Chen, et al.
Cyhoeddwyd: (2012-01-01)

The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $${\text {Ca}}^{2+}$$ Ca 2 + dynamics
gan: Maryam Saadati, et al.
Cyhoeddwyd: (2021-05-01)

Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.
gan: Aparna Nittala, et al.
Cyhoeddwyd: (2007-01-01)

Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology
gan: N. Haq, et al.
Cyhoeddwyd: (2024-11-01)

Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets.
gan: Joseph P McKenna, et al.
Cyhoeddwyd: (2016-10-01)

Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.
gan: Göpel, S, et al.
Cyhoeddwyd: (2004)

Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function.
gan: Krishana S Sankar, et al.
Cyhoeddwyd: (2019-01-01)

Plasma membrane Ca2+ ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse
gan: Wang, Y, et al.
Cyhoeddwyd: (2017)

Flipping the switch on the hub cell: Islet desynchronization through cell silencing.
gan: Janita P Hogan, et al.
Cyhoeddwyd: (2021-01-01)

Editorial: The pancreatic islet – a multifaceted hub of inter-cellular communication
gan: Quan Zhang, et al.
Cyhoeddwyd: (2023-05-01)

Reprogramming of non-beta islet cells
gan: Pedro Herrera
Cyhoeddwyd: (2021-11-01)

Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells.
gan: Sylvain J Le Marchand, et al.
Cyhoeddwyd: (2012-01-01)

Zn2+ is essential for Ca2+ oscillations in mouse eggs
gan: Hiroki Akizawa, et al.
Cyhoeddwyd: (2023-12-01)

Encapsulated human islets in alginate fiber maintain long-term functionality
gan: Junko Nishida, et al.
Cyhoeddwyd: (2024-03-01)

Microwell culture platform maintains viability and mass of human pancreatic islets
gan: Hiroyuki Kato, et al.
Cyhoeddwyd: (2022-11-01)

Reestablishment of Microenvironment is Necessary to Maintain In Vitro and In Vivo Human Islet Function
gan: Nalú Navarro-Alvarez, et al.
Cyhoeddwyd: (2008-01-01)

Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced
gan: Peter Seiron, et al.
Cyhoeddwyd: (2019-10-01)

Fibrin plus perfluorocarbons: new microenvironment to maintain the viability of pancreatic islets before transplantation
gan: Maillard, E, et al.
Cyhoeddwyd: (2010)

Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.
gan: Gall, D, et al.
Cyhoeddwyd: (1999)

Roles of Islet Toll-Like Receptors in Pig to Mouse Islet Xenotransplantation
gan: Han Ro, et al.
Cyhoeddwyd: (2013-09-01)

ELECTRICAL BURSTING IN ISLET BETA-CELLS - REPLY
gan: Rorsman, P, et al.
Cyhoeddwyd: (1992)

Comparison of different hyaluronic acid-based matrices to maintain human islet survival in macroencapsulation devices
gan: Brandhorst, D, et al.
Cyhoeddwyd: (2022)

Beta Oscillations, Timing and Stuttering
gan: Andrew C Etchell, et al.
Cyhoeddwyd: (2015-01-01)

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
gan: Salem, V, et al.
Cyhoeddwyd: (2019)

Maintenance of Mouse, Rat, and Pig Pancreatic Islet Functions by Coculture with Human Islet-Derived Fibroblasts
gan: Atsushi Miki, et al.
Cyhoeddwyd: (2006-04-01)

Beta Oscillations
gan: Flavio Fröhlich
Cyhoeddwyd: (2018-08-01)

Feasibility of maintaining satellite altimetry calibration site based on qianliyan islet at the Yellow Sea
gan: Bin Guan, et al.
Cyhoeddwyd: (2023-05-01)