Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Εμφάνιση άλλων εκδόσεων (1)

To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17beta-HSD (17beta-hydroxysteroid dehydrogenase) activity. 17b...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Lukacik, P, Keller, B, Bunkoczi, G, Kavanagh, K, Lee, W, Adamski, J, Oppermann, U
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2007
Θέματα:	chemistry Models, Molecular Amino Acid Sequence Structural Homology, Protein Cytosol Protein Structure, Tertiary enzymology NAD Ligands Cell Line Sequence Alignment genetics Kinetics Molecular Sequence Data Gene Expression Protein Structure, Secondary Binding Sites 17-Hydroxysteroid Dehydrogenases Crystallography, X-Ray Organ Specificity isolation and purification Oxidation-Reduction metabolism

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