Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

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To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17beta-HSD (17beta-hydroxysteroid dehydrogenase) activity. 17b...

書目詳細資料
Main Authors:	Lukacik, P, Keller, B, Bunkoczi, G, Kavanagh, K, Lee, W, Adamski, J, Oppermann, U
格式:	Journal article
語言:	English
出版:	2007
主題:	chemistry Models, Molecular Amino Acid Sequence Structural Homology, Protein Cytosol Protein Structure, Tertiary enzymology NAD Ligands Cell Line Sequence Alignment genetics Kinetics Molecular Sequence Data Gene Expression Protein Structure, Secondary Binding Sites 17-Hydroxysteroid Dehydrogenases Crystallography, X-Ray Organ Specificity isolation and purification Oxidation-Reduction metabolism

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