Vav regulates peptide-specific apoptosis in thymocytes.
The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells. Gene-targeted mice lacking Vav have a severe defect in positive and negative selection of T cell antigen receptor transgenic thymo...
主要な著者: | , , , , , , , , , |
---|---|
フォーマット: | Journal article |
言語: | English |
出版事項: |
1998
|