Investigating the role of lipids and small-molecule ligands in hedgehog signalling using molecular dynamics simulations
The Hedgehog (HH) signalling pathway orchestrates cellular patterning during embryonic development and adult stem cell programming. Sonic hedgehog (SHH) is the principle morphogenic ligand responsible for paracrine induction of HH signalling. Pathway dysregulation results in multiple cancer patholog...
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| Format: | Thesis |
| Language: | English |
| Published: |
2022
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