Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.

The RAS proto-oncogene Harvey rat sarcoma viral oncogene homolog (HRAS) encodes a small GTPase that transduces signals from cell surface receptors to intracellular effectors to control cellular behavior. Although somatic HRAS mutations have been described in many cancers, germline mutations cause Co...

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Bibliographic Details
Main Authors: Giannoulatou, E, McVean, G, Taylor, I, McGowan, S, Maher, G, Iqbal, Z, Pfeifer, S, Turner, I, Burkitt Wright, E, Shorto, J, Itani, A, Turner, K, Gregory, L, Buck, D, Rajpert-De Meyts, E, Looijenga, L, Kerr, B, Wilkie, A, Goriely, A
Format: Journal article
Language:English
Published: 2013

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