The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.

The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.

Integrins are cell surface receptors crucial for cell migration and adhesion. They are activated by interactions of the talin head domain with the membrane surface and the integrin β cytoplasmic tail. Here, we use coarse-grained molecular dynamic simulations and nuclear magnetic resonance spectrosco...

书目详细资料
Main Authors:	Kalli, A, Wegener, K, Goult, B, Anthis, N, Campbell, I, Sansom, MS
格式:	Journal article
语言:	English
出版:	2010

相似书籍

Structural diversity in integrin/talin interactions.
由: Anthis, N, et al.
出版: (2010)

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
由: Anthis, N, et al.
出版: (2009)

The structure of an interdomain complex that regulates talin activity.
由: Goult, B, et al.
出版: (2009)

An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
由: Oxley, C, et al.
出版: (2008)

A helix heterodimer in a lipid bilayer: prediction of the structure of an integrin transmembrane domain via multiscale simulations.
由: Kalli, A, et al.
出版: (2011)

Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.
由: Anthis, N, et al.
出版: (2009)

Computational studies of talin-mediated integrin activation
由: Kalli, A
出版: (2013)

Structural basis of integrin activation by talin.
由: Wegener, K, et al.
出版: (2007)

Outer membrane proteins: comparing X-ray and NMR structures by MD simulations in lipid bilayers.
由: Cox, K, et al.
出版: (2008)

Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices.
由: Antreas C Kalli, et al.
出版: (2013-10-01)

The integrin receptor in biologically relevant bilayers: insights from molecular dynamics simulations
由: Kalli, A, et al.
出版: (2016)

The molecular basis of filamin binding to integrins and competition with talin.
由: Kiema, T, et al.
出版: (2006)

Structural determinants of integrin recognition by talin.
由: García-Alvarez, B, et al.
出版: (2003)

The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
由: Stephanie J Ellis, et al.
出版: (2014-11-01)

Multiscale simulations suggest a mechanism for integrin inside-out activation.
由: Kalli, A, et al.
出版: (2011)

Interaction of monotopic membrane enzymes with a lipid bilayer: a coarse-grained MD simulation study.
由: Balali-Mood, K, et al.
出版: (2009)

The talin-tail interaction places integrin activation on FERM ground.
由: Campbell, I, et al.
出版: (2004)

Structure and dynamics of the pore-lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles.
由: Law, R, et al.
出版: (2000)

Coarse-grained MD simulations of membrane protein-bilayer self-assembly.
由: Scott, K, et al.
出版: (2008)

Mechanism of integrin activation by talin and its cooperation with kindlin
由: Fan Lu, et al.
出版: (2022-04-01)

Data supporting beta-amyloid dimer structural transitions and protein–lipid interactions on asymmetric lipid bilayer surfaces using MD simulations on experimentally derived NMR protein structures
由: Sara Y. Cheng, et al.
出版: (2016-06-01)

The mechanical response of talin
由: Mingxi Yao, et al.
出版: (2016-07-01)

Talin and kindlin : batman and robin of Mac1 integrin activation?
由: Henni Djunaidi.
出版: (2009)

Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.
由: Ulmer, T, et al.
出版: (2003)

The tail of integrin activation.
由: Anthis, N, et al.
出版: (2011)

Structural studies of integrin activation
由: Anthis, N, et al.
出版: (2009)

Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer.
由: Forrest, L, et al.
出版: (2000)

Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
由: Yuanyuan Wu, et al.
出版: (2025-01-01)

Simulation studies of the interaction of antimicrobial peptides and lipid bilayers.
由: La Rocca, P, et al.
出版: (1999)

Peptide nanopores and lipid bilayers: interactions by coarse-grained molecular-dynamics simulations.
由: Klingelhoefer, J, et al.
出版: (2009)

The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
由: Hao Sun, et al.
出版: (2022-06-01)

Integrin activating molecule-talin1 promotes skin fibrosis in systemic sclerosis
由: Dan Xu, et al.
出版: (2024-05-01)

Interaction of diverse voltage sensor homologs with lipid bilayers revealed by self-assembly simulations.
由: Mokrab, Y, et al.
出版: (2011)

Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion
由: Lisa S. Fischer, et al.
出版: (2021-02-01)

PHYS 147-Interactions of ion channels with lipids: MD simulation studies
由: Sansom, M
出版: (2007)

Conformational dynamics of a lipid-interacting protein: MD simulations of saposin B.
由: Stokeley, D, et al.
出版: (2007)

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease
由: Charles Ellis, et al.
出版: (2024-11-01)

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
由: Liang Zhu, et al.
出版: (2017-11-01)

Coarse-grained molecular dynamics simulations of the energetics of helix insertion into a lipid bilayer.
由: Bond, P, et al.
出版: (2008)

Investigating the roles of cytoplasmic proteins talin and kindlin3 in integrin LFA-1 activation
由: Li, Yan Feng
出版: (2011)