Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.

Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.

Susceptibility to coeliac disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined our f...

Podrobná bibliografie
Hlavní autoři:	Popat, S, Hearle, N, Hogberg, L, Braegger, C, O'Donoghue, D, Falth-Magnusson, K, Holmes, G, Howdle, P, Jenkins, H, Johnston, S, Kennedy, N, Kumar, P, Logan, R, Marsh, M, Mulder, C, Torinsson Naluai, A, Sjoberg, K, Stenhammar, L, Walters, JR, Jewell, D, Houlston, R
Médium:	Journal article
Jazyk:	English
Vydáno:	2002

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