Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.

A major limitation of many self-assembling nonviral gene transfer formulations is that they are commonly prepared at relatively low component concentrations. While this typically has little impact on their use in cell culture, it can severely limit the progress of in vivo studies. In order to overco...

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Bibliographic Details
Main Authors: Davies, L, McLachlan, G, Sumner-Jones, S, Ferguson, D, Baker, A, Tennant, P, Gordon, C, Vrettou, C, Baker, E, Zhu, J, Alton, E, Collie, D, Porteous, D, Hyde, S, Gill, DR
Format: Journal article
Language:English
Published: 2008