Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection.

Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection.

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BACKGROUND: Rare human immunodeficiency virus type 1 (HIV-1)-infected individuals who maintain control of viremia without therapy show potent CD8+ T-cell-mediated suppression of viral replication in vitro. Whether this is a determinant of the rate of disease progression in viremic individuals is unk...

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Bibliographic Details
Main Authors: Yang, H, Wu, H, Hancock, G, Clutton, G, Sande, N, Xu, X, Yan, H, Huang, X, Angus, B, Kuldanek, K, Fidler, S, Denny, T, Birks, J, McMichael, A, Dorrell, L
Format: Journal article
Language:English
Published: 2012

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