Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection.
BACKGROUND: Rare human immunodeficiency virus type 1 (HIV-1)-infected individuals who maintain control of viremia without therapy show potent CD8+ T-cell-mediated suppression of viral replication in vitro. Whether this is a determinant of the rate of disease progression in viremic individuals is unk...
Main Authors: | Yang, H, Wu, H, Hancock, G, Clutton, G, Sande, N, Xu, X, Yan, H, Huang, X, Angus, B, Kuldanek, K, Fidler, S, Denny, T, Birks, J, McMichael, A, Dorrell, L |
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Format: | Journal article |
Language: | English |
Published: |
2012
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