Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.
The design, synthesis, and structural analysis of a new foldamer that mimics an extended beta-sheet are presented. The nonpeptidic mimetic is based on a series of 2,2-disubstituted-indolin-3-one groups linked through their 4,7-positions by an alkyne spacer. An intramolecular hydrogen bond between th...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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