Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells. Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, inc...

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Bibliographic Details
Main Authors: Cribbs, AP, Filippakopoulos, P, Philpott, M, Wells, G, Penn, H, Oerum, H, Valge-Archer, V, Feldmann, M, Oppermann, U
Format: Journal article
Language:English
Published: Frontiers Media 2021