Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, and systematically compared these with human DHS maps from orthologous compartments. We found that the mouse and human genomes have u...

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Bibliographic Details
Main Authors:	Vierstra, J, Rynes, E, Sandstrom, R, Zhang, M, Canfield, T, Hansen, R, Stehling-Sun, S, Sabo, P, Byron, R, Humbert, R, Thurman, R, Johnson, A, Vong, S, Lee, K, Bates, D, Neri, F, Diegel, M, Giste, E, Haugen, E, Dunn, D, Wilken, MS, Josefowicz, S, Samstein, R, Chang, K, Eichler, E
Format:	Journal article
Language:	English
Published:	2014

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

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