Predicting substrates for orphan solute carrier proteins using multi-omics datasets

Solute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC proteins are ‘orphans’ whose substrates are u...

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Bibliographic Details
Main Authors: Zhang, Y, Newstead, S, Sarkies, P
Format: Journal article
Language:English
Published: BioMed Central 2025