Demonstration of the blood-stage controlled human malaria infection model to assess efficacy of the Plasmodium falciparum AMA1 vaccine FMP2.1/AS01

Demonstration of the blood-stage controlled human malaria infection model to assess efficacy of the Plasmodium falciparum AMA1 vaccine FMP2.1/AS01

 Mosquito-bite controlled human malaria infection (CHMI) models have been widely used to assess efficacy of pre-erythrocytic vaccine candidates in small proof-of-concept Phase IIa clinical trials. Efficacy testing of blood-stage vaccines, however, has generally relied on larger-scale Phase IIb field...

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Bibliografski detalji
Glavni autori: Payne, R, Milne, K, Elias, S, Edwards, N, Douglas, A, Brown, R, Silk, S, Biswas, S, Miura, K, Roberts, R, Rampling, T, Venkatraman, N, Hodgson, S, Labbé, G, Halstead, F, Poulton, I, Nugent, F, de Graaf, H, Sukhtankar, P, Williams, N, Ockenhouse, C, Kathcart, A, Qabar, A, Waters, N, Soisson, L, Birkett, A, Cooke, G, Faust, S, Woods, C, Ivinson, K, McCarthy, J, Diggs, C, Vekemans, J, Long, C, Hill, A, Lawrie, A, Dutta, S, Draper, S
Format: Journal article
Jezik:English
Izdano: Oxford University Press 2016

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