Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria.

BACKGROUND: Artemisinin-based combination therapy (ACT) is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin derivative, artesunate, has been diminished due to parasite resistance. This reducti...

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Những tác giả chính: Jamsen, K, Duffull, S, Tarning, J, Lindegardh, N, White, N, Simpson, J
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: BioMed Central 2012