Asymmetric synthesis of d-fagomine and its diastereoisomers

A divergent strategy for the asymmetric syntheses of d-fagomine and three of its diastereoisomers has been developed. The diastereoselective conjugate addition of an enantiopure lithium amide to an α,β-unsaturated ester was used as the key step to install the correct configuration required for the C...

Full description

Bibliographic Details
Main Authors: Davies, S, Fletcher, A, Kennedy, M, Roberts, P, Thomson, J
Format: Journal article
Published: Elsevier 2018