C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

The Ho crossed aldol condensation provides access to a series of carbon branched iminosugars as exemplified by the synthesis of enantiomeric pairs of isoDMDP, isoDGDP, and isoDAB, allowing comparison of their biological activities with three linear isomeric natural products DMDP, DGDP, and DAB and t...

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Bibliographic Details
Main Authors: Jenkinson, S, Best, D, Saville, A, Mui, J, Martínez, R, Nakagawa, S, Kunimatsu, T, Alonzi, D, Butters, T, Norez, C, Becq, F, Blériot, Y, Wilson, F, Weymouth-Wilson, A, Kato, A, Fleet, G
Format: Journal article
Language:English
Published: 2013