Potent ex vivo activity of naphthoquine and methylene blue against drug-resistant clinical isolates of Plasmodium falciparum and Plasmodium vivax

The 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitro efficacies against Plasmodium falciparum, but susceptibility data for P. vivax are limited. The species- and stage-specific ex vivo activities of NQ and MB were assessed using a modified schizont mat...

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Main Authors: Wirjanata, G, Sebayang, BF, Chalfein, F, Prayoga, Handayuni, I, Trianty, L, Kenangalem, E, Noviyanti, R, Campo, B, Poespoprodjo, J, Möhrle, JJ, Price, R, Marfurt, J
Format: Journal article
Language:English
Published: American Society for Microbiology 2015