Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or “orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases. This increase in DNA-sequenced big data has given rise to significant challenges in the applied field of natural product gen...

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Bibliographic Details
Main Authors: Tang, X, Li, J, Millán-Aguiñaga, N, Zhang, J, O’Neill, E, Ugalde, J, Jensen, P, Mantovani, S, Moore, B
Format: Journal article
Published: American Chemical Society 2015