Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1 surface ant...

書誌詳細
主要な著者:	Scanlan, C, Ritchie, G, Baruah, K, Crispin, M, Harvey, D, Singer, B, Lucka, L, Wormald, M, Wentworth, P, Zitzmann, N, Rudd, P, Burton, D, Dwek, R
フォーマット:	Journal article
言語:	English
出版事項:	Elsevier 2007

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