Oral hydrocortisone administration in children with classic 21-hydroxylase deficiency leads to more synchronous joint GH and cortisol secretion.

In humans, GH and cortisol are secreted in a pulsatile fashion and a mutual bidirectional interaction between the GH/IGF-I axis and hypothalamic-pituitary-adrenal axis has been established. Classic congenital adrenal hyperplasia (CAH) is characterized by a defect in the synthesis of glucocorticoids...

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Những tác giả chính: Charmandari, E, Pincus, S, Matthews, DR, Johnston, A, Brook, C, Hindmarsh, P
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2002