High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets

High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets

Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model for the environment experienced by human islets i...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Brandhorst, D, Brandhorst, H, Mullooly, N, Acreman, S, Johnson, P
التنسيق:	Journal article
اللغة:	English
منشور في:	SAGE Publications 2016

مواد مشابهة

High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets
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Successful human islet isolation utilizing recombinant collagenase.
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Pig Pancreas Oxygenation at 20°C Increases Islet ATP Generation but Deteriorates Islet Function
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Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
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Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
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Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
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Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival
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Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
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Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
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Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.
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Assessment of Intracellular Insulin Content during All Steps of Human Islet Isolation Procedure
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Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.
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Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
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