High-accuracy HLA type inference from whole-genome sequencing data using population reference graphs

Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many autoimmune and infectious disease phenotypes, is an important element of the immunological distinction between self and non-self, and shapes immune epitope repertoires. Determining the allelic state of the HLA genes...

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Main Authors: Dilthey, A, Gourraud, P, Mentzer, A, Cereb, N, Iqbal, Z, McVean, G
格式: Journal article
出版: Public Library of Science 2016