Strong male bias drives germline mutation in chimpanzees
Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10−8 per base pair per generation, with every additional year of father’s age contributing two mutations across the genome and males contributing three...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2014
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| _version_ | 1817931269712904192 |
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| author | Venn, O Turner, I de Groot, N Bontrop, R Mathieson, I McVean, G |
| author_facet | Venn, O Turner, I de Groot, N Bontrop, R Mathieson, I McVean, G |
| author_sort | Venn, O |
| collection | OXFORD |
| description | Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10−8 per base pair per generation, with every additional year of father’s age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10−8 per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father’s age. Thus, mutation rates and patterns differ between closely related species. |
| first_indexed | 2024-03-07T05:13:49Z |
| format | Journal article |
| id | oxford-uuid:dc769f54-2350-40af-8d7c-38d4a9b65f13 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:19:20Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:dc769f54-2350-40af-8d7c-38d4a9b65f132024-10-30T09:33:19ZStrong male bias drives germline mutation in chimpanzeesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dc769f54-2350-40af-8d7c-38d4a9b65f13EnglishSymplectic Elements at OxfordAmerican Association for the Advancement of Science2014Venn, OTurner, Ide Groot, NBontrop, RMathieson, IMcVean, GGermline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10−8 per base pair per generation, with every additional year of father’s age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10−8 per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father’s age. Thus, mutation rates and patterns differ between closely related species. |
| spellingShingle | Venn, O Turner, I de Groot, N Bontrop, R Mathieson, I McVean, G Strong male bias drives germline mutation in chimpanzees |
| title | Strong male bias drives germline mutation in chimpanzees |
| title_full | Strong male bias drives germline mutation in chimpanzees |
| title_fullStr | Strong male bias drives germline mutation in chimpanzees |
| title_full_unstemmed | Strong male bias drives germline mutation in chimpanzees |
| title_short | Strong male bias drives germline mutation in chimpanzees |
| title_sort | strong male bias drives germline mutation in chimpanzees |
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