Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.

The New Delhi metallo-β-lactamase (NDM-1) is involved in the emerging antibiotic resistance problem. Development of metallo-β-lactamases (MBLs) inhibitors has proven challenging, due to their conformational flexibility. Here we report site-selective labeling of NDM-1 with 1,1,1-trifluoro-3-bromo ace...

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Bibliographic Details
Main Authors:	Rydzik, A, Brem, J, van Berkel, S, Pfeffer, I, Makena, A, Claridge, T, Schofield, C
Format:	Journal article
Language:	English
Published:	Wiley 2014

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